Serif Biomedicines logo
Biotech/Pharma
HealthTech

Serif Biomedicines

Pioneering Modified DNA therapeutics

Cambridge· 1 role

CORE INFO

$50M
Total Funding
2021
Founded
Cambridge, Massachusetts, USA
Headquarters

Serif Biomedicines is a biotechnology company focused on developing Modified DNA therapeutics to address challenges in DNA therapies, such as immunogenicity and inefficient nuclear access, without altering the cell's genome. Their innovative approach targets rare diseases and immune programming, appealing to healthcare and biotechnology sectors.

  • Serif Biomedicines emerged from five years of platform development with an initial commitment of $50 million from Flagship Pioneering.flagshippioneering.com
  • The company's Modified DNA platform is protected by more than 20 patent families, including issued U.S. patents.flagshippioneering.com

WHY WE WOULD WORK AT SERIF BIOMEDICINES

Pioneering Technology

Join a team at the forefront of biotechnology, developing Modified DNA therapeutics that combine mRNA and gene therapy to tackle rare diseases.

Meaningful Impact

Contribute to groundbreaking solutions that aim to improve patient outcomes and address significant healthcare challenges.

Innovative Learning Environment

Work alongside experts in nucleic acid chemistry and synthetic biology, fostering continuous learning and professional growth.

Strong Financial Backing

Benefit from a solid foundation with $50 million in initial funding from Flagship Pioneering, ensuring resources for ambitious projects.

Cutting-Edge Research

Engage in advanced research protected by over 20 patent families, positioning you at the cutting edge of genetic medicine.

Collaborative Culture

Be part of a dynamic team that values collaboration and innovation, driving collective success in a supportive environment.

MARKET AND TRACTION

TOTAL ADDRESSABLE MARKET

  • Serif Biomedicines focuses on developing therapeutics for rare diseases and immune programming, indicating a significant market potential in the healthcare and biotechnology sectors.

  • The innovative Modified DNA platform aims to address traditional challenges in DNA therapies, suggesting a broad applicability across various therapeutic areas.
  • KEY METRICS

    ✦ KEY METRIC
  • Founded in 2021, Serif Biomedicines has quickly established itself in the biotechnology field with a strong foundation of five years of platform development.

  • The company has secured an initial funding commitment of $50 million from Flagship Pioneering to support its innovative research and development efforts.
  • COMPETITIVE ADVANTAGE

  • Serif's Modified DNA platform combines elements of mRNA and gene therapy, offering a unique approach that addresses immunogenicity and nuclear access challenges.

  • The platform is protected by more than 20 patent families, including issued U.S. patents, providing a strong intellectual property position in the market.
  • NOTABLE ACHIEVEMENTS

  • In May 2026, Serif presented preclinical data at the American Society of Gene & Cell Therapy (ASGCT), demonstrating the tolerability and therapeutic effects of their Modified DNA platform in non-human primates.

  • The data showcased sustained gene expression after intravenous administration, highlighting the potential of their technology in clinical applications.
  • MARKET POSITION

  • Serif Biomedicines is positioned as a pioneer in the biotechnology industry, focusing on a new class of medicines through Modified DNA therapeutics.

  • The company's innovative approach and backing from Flagship Pioneering enhance its credibility and visibility in a competitive landscape.
  • PRODUCT AND TECH

    Modified DNA Therapeutics

    Serif Biomedicines is pioneering Modified DNA as a new class of medicines, combining elements of mRNA and gene therapy to create therapeutics that are programmable, scalable, durable, and redosable.

    Nucleic Acid Chemistry

    The company integrates advanced nucleic acid chemistry into its platform to enhance the efficacy and safety of its Modified DNA therapeutics, addressing traditional challenges in DNA therapies.

    Synthetic Biology Integration

    Serif employs synthetic biology techniques to design and optimize its Modified DNA constructs, enabling precise control over therapeutic outcomes and improved delivery mechanisms.

    Delivery Science Innovations

    Innovative delivery science is a core component of Serif's approach, focusing on overcoming barriers to nuclear access and ensuring effective therapeutic delivery without altering the cell's genome.

    Artificial Intelligence Applications

    Serif utilizes artificial intelligence to streamline drug discovery processes, enhancing the identification and development of therapeutics targeting rare diseases and immune programming.

    COMPANY CULTURE

    Values

  • Innovation is at the core of our mission

  • Commitment to addressing rare diseases

  • Integrity in scientific research and development

  • Collaboration across disciplines to drive success

  • Respect for the individual and their contributions
  • Operating Principles

  • Focus on pioneering new therapeutic approaches

  • Emphasis on programmable and scalable solutions

  • Dedication to maintaining genome integrity

  • Integration of cutting-edge technologies like AI and synthetic biology

  • Continuous improvement through data-driven insights
  • Benefits

  • Opportunity to work on groundbreaking biotechnology

  • Collaborative and inclusive work environment

  • Access to professional development and learning resources

  • Competitive compensation and benefits package

  • Support for work-life balance and employee well-being
  • Learning & Growth

  • Encouragement of continuous learning and innovation

  • Opportunities for cross-disciplinary collaboration

  • Regular training sessions and workshops

  • Mentorship programs with industry leaders

  • Support for attending conferences and seminars
  • Team Cadence

  • Regular team meetings to foster communication

  • Agile project management to adapt to changes

  • Open-door policy for feedback and ideas

  • Celebrating milestones and achievements together

  • Encouraging a culture of transparency and trust
  • HIRING SIGNAL

    1
    Open roles on their careers page
    Snapshot via live ATS poll
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    Net new roles in the last 90 days
    Available once weekly history accrues
    90-Day VelocityV2 · BACKFILL
    Trend builds weekly as historical rows accrue
    By Function
    Breakdown of open roles
    Other · 1
    Top Locations
    Where hiring is concentrated
    Remote-eligible postings counted separately
    Cambridge, MA
    1
    SourcesGreenhouseLeverAshbyWorkableSmartRecruitersRipplingRecruiteeFallback · Wellfound, YC Work-at-a-Startup, careers-page scrape

    KEY COMPANY ANNOUNCEMENTS

    Filter
    4 announcements · ranked by importance
    Apr 21, 2026PRODUCTSerif | Flagship Pioneering Launches Serif Biomedicines to Establish…serifbiomedicines.com
    Apr 21, 2026FUNDINGFlagship Pioneering Launches Serif Biomedicines… | Flagship Pioneeringflagshippioneering.com
    Apr 21, 2026PRESSSerif Biomedicines launches to reformat DNA medicinescen.acs.org
    Apr 21, 2026EXEC HIRESerif | Teamserifbiomedicines.com